Brussels Airlines, Belgium Airline Companies. Brussels Airlines is the flag carrier and largest airline of Belgium based and headquartered at Brussels Airport. Brussels Airlines is the main Belgium airline company that operates scheduled flights. About Brussels Airlines Fleet; The Airbus A330-300 is the biggest aircraft this kind of aircraft normally being used for long haul flights and Brussels Airlines uses this aircrafts flights to and from North America, India and the African continent. So this Airbus A330-300 models remains Brussels Airlines’ first choice for long distance flights. Air Antwerp is a regional airlines from Antwerp, Belgium.